You want to make the attack stop as quickly as possible, right? Somebody trying to kill your or somebody else, you want to stop them from doing that right freakin’ NOW, right?
Two ways to do that: Make them decide to stop (by threat or application of force) or inhibit their physical ability to continue the attack (by threat or application of force).
We can’t depend on our action making them decide to stop. We have to plan on the basis of disrupting them physically.
Surest way to do that is to hit them in the Central Nervous System (CNS).
CNS hits are the gold standard for combat accuracy. Train, plan, practice to focus on hitting CNS from wherever you’re at when the fight starts.
Center of Mass? That’s what you get on the way to hitting CNS.